This test allows us to determine if there is altered sperm generation (meiosis) in male patients.
Fluorescence in situ hybridization (FISH) involves the study of sperm chromosomes using fluorescent DNA probes and fluorescence microscopy with the aim of analyzing numerical chromosomal abnormalities.
This allows us to verify if there are alterations in the process of meiosis (spermatogenesis). Chromosomes 13, 18, 21, X, and Y are routinely studied by FISH.
An altered result in a sperm FISH study indicates that sperm cell manufacturing (the process of meiosis called spermatogenesis) is altered, resulting in the production of a higher than usual number of sperm cells with chromosome abnormalities known as aneuploid sperm.
This will result in the production of fewer chromosomally normal (euploid) embryos after fertilization, thereby decreasing the success rate of the reproductive process. In these cases, we recommended considering pre-implantation genetic testing for aneuploidy (PGT-A).
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