KIR-HLA-C

What is it?

KIR-HLA-C

The weight of the intrauterine immunological factor in implantation problems is becoming increasingly understood.

Although significant controversy regarding this issue remains, it seems that patients who have an AA genotype in ‘natural killer’ (NK) cell immunoglobulin-like receptor (KIR) family genes may reject embryos that have an HLA-C gene C2C2 genotype, which causes an increase in repeated implantation failures and a decrease in live birth rates when performing a two-embryo transfer versus a single-embryo transfer.

Step-by-Step

How does it work?

1.
Get in touch with us or your doctor.
2.
We carry out genetic counselling and get your informed consent for the test.
3.
Blood is drawn at one of our centers.
4.
Our team will contact you or your doctor to discuss the results.

If an AA result is obtained in the KIR ligand test for the patient, the HLA-C haplotype of her partner or the gamete donor can be determined.

In this case, it would be necessary to consider avoiding the use of gametes with a C2C2 genotype or, where appropriate, the transfer of a single embryo.